Cell cycle phosphorylation of mitotic exit network (MEN) proteins
نویسندگان
چکیده
منابع مشابه
Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.
Inactivation of cyclin-dependent kinase (Cdk) 1 promotes exit from mitosis and establishes G1. Proteolysis of cyclin B is the major known mechanism that turns off Cdk1 during mitotic exit. Here, we show that mitotic exit also activates pathways that catalyze inhibitory phosphorylation of Cdk1, a mechanism previously known to repress Cdk1 only during S and G2 phases of the cell cycle. We present...
متن کاملThe mitotic exit network
What is it? The mitotic exit network – commonly known by the acronym MEN — is a signal transduction cascade which triggers the exit of mitosis. The MEN has been characterized in the budding yeast Saccharomyces cerevisiae, and the protein names below refer to components from this species, though many are conserved in vertebrates. The main switch of this cascade is the small G protein Tem1 and it...
متن کاملA role for cell polarity proteins in mitotic exit.
The budding yeast mitotic exit network (MEN) is a signal transduction cascade that controls exit from mitosis by facilitating the release of the cell cycle phosphatase Cdc14 from the nucleolus. The G protein Tem1 regulates MEN activity. The Tem1 guanine nucleotide exchange factor (GEF) Lte1 associates with the cortex of the bud and activates the MEN upon the formation of an anaphase spindle. Th...
متن کاملPhosphorylation of Xenopus p31 potentiates mitotic checkpoint exit
p31 plays an important role in spindle assembly checkpoint (SAC) silencing. However, how p31’s activity is regulated remains unclear. Here we show that the timing of M-phase exit in Xenopus egg extracts (XEEs) depends upon SAC activity, even under conditions that are permissive for spindle assembly. p31 antagonizes the SAC, promoting XEE progression into anaphase after spindles are fully formed...
متن کاملCell cycle-regulated proteolysis of mitotic target proteins.
The ubiquitin-dependent proteolysis of mitotic cyclin B, which is catalyzed by the anaphase-promoting complex/cyclosome (APC/C) and ubiquitin-conjugating enzyme H10 (UbcH10), begins around the time of the metaphase-anaphase transition and continues through G1 phase of the next cell cycle. We have used cell-free systems from mammalian somatic cells collected at different cell cycle stages (G0, G...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.20.17790